Dinner Lecture: Emerging Hybrid Separation Techniques for the Analysis of New Psychoactive Substances
The Chicago Chromatography Discussion Group invites you to an in-person Dinner Meeting
Speaker: Professor Ira Lurie Ph.D. Adjunct Professor, Research Professor Department of Forensic Sciences George Washington University
Location: Westwood Tavern Schaumburg, IL
Date: Tuesday December 5th, 2023 Time: 6pm – 9pm
|Join us for a dinner and networking event on December 5th, 2023, at the Westwood Tavern in Schaumburg, IL. For screening and confirmation purposes hybrid techniques employing a separation and detection step are routinely employed. In this vein the specificity of analysis depends on the performance of both techniques working in tandem. Ultra-high performance supercritical fluid chromatography (UHPSFC) and ultra-high performance liquid chromatography (UHPLC) provide for uncorrelated separations compared to gas chromatography (GC) and thus a complementary technique to gas phase separations which is very useful for the analysis of novel psychoactive substances (NPS), particularly for positional isomers and diastereomers. Ultra-high performance supercritical fluid chromatography has been found to outperform UHPLC and GC for the separation of these analytes. The use of flip flop chromatography allows for uncorrelated UHPLC multi-modal separations on the same column without changing the contents of the solvent reservoir. Electron ionization (EI) mass spectrometry for several classes of emerging drugs is lacking in the production of molecular ions. Techniques such as cold EI MS coupled to GC, and electrospray ionization (ESI) MS coupled to UHPLC and UHPSFC can overcome this limitation. Electron ionization mass spectrometry can be problematic for distinguishing positional isomers and diastereomers, for which vacuum ultraviolet (VUV) detection coupled with GC, and ultraviolet detection coupled to UHPLC, and UHPSFC can offer solutions. The use of a portable LC employing two capillary columns in series with dual wavelength UV detection will be discussed.
|Professor Ira Lurie received his BA in chemistry from Queens College in Queens, New York, and his MS in chemistry from Rutgers University, New Brunswick New Jersey. Dr. Lurie received his Ph.D. in chemistry from the University of Amsterdam, The Netherlands, under the direction of Professor Peter Schoenmakers, where his thesis described the use of ultra-high performance liquid chromatography (UHPLC) for the analysis of seized drugs. He is retired from the United States Drug Enforcement Administration where he served for almost 40 years as both a forensic chemist and a research chemist developing methods liquid phase techniques for drug profiling. During his tenure with the DEA, he served as the agency’s expert in liquid phase separations. Along with Dr. Bob Weinberger Dr. Lurie pioneered the use of capillary electrophoresis for seized drug analysis. Professor Lurie has co-edited a book, authored, or co-authored 7 book chapters and over 80 peer reviewed articles. In this vein, he was recently listed as one of the top 25 most cited authors in forensic science in the United States. Dr. Lurie is a fellow of the American Academy of Forensic Sciences (AAFS) from whom he was the winner of the 2015 Paul L. Kirk Award, the highest form of recognition from the Criminalistics Section of the AAFS. His research interests include the investigation of novel separation and detection techniques for drug analysis i.e., ultra-high performance supercritical fluid chromatography (UHPSFC), multi-modal separations, the use of a portable liquid chromatograph, and gas chromatography (GC) coupled to cold electron ionization mass spectrometry and/or vacuum ultraviolet detection.