Join us for a dinner and networking event Thursday April 18, 2024, at the Westwood Tavern in Schaumburg, IL. The topics discussed will cover sample prep techniques for non-targeted analysis of PFAS using combustion ion chromatography. Due to their environmental persistence and potential implications on human health, the analysis of per-and polyfluoroalkyl substances, or PFAS, in the environment remains critical. Targeted analysis using LC-MS/MS has long been the analytical method of choice, due to its high sensitivity and specificity. With more than 3000 potential PFAS-type compounds, targeted analysis does not always allow for the assessment of the total impact of these compounds. Because of this, there has been increasing interest by regulatory committees in non-targeted analysis techniques, such as quantifying total organic fluorine (TOF), as a PFAS impact assessment. Combustion Ion Chromatography, or CIC, allows for the sensitive quantitation of TOF, ranging from single ppb to percent levels. In this technique, samples are combusted in a high temperature oven, where organofluorine bonds are broken to produce HF, which is subsequently absorbed into solution and analyzed by IC for fluorine. Prior to analysis by IC, inorganic, or free fluoride must be separated from the sample to prevent interference. A variety of techniques exist to accomplish removal of inorganic fluoride, such as the AOF (adsorbable organic fluorine) method, which captures organofluorine compounds on an activated charcoal bed and allows for removal of free fluoride through a rinsing step. The charcoal can then be analyzed by CIC. Other methods have also been investigated to further improve recovery of TOF, allowing for the non-targeted identification of PFAS compounds ranging from C1-C16+. A comparison of these methods will be presented.
Dr. Gandhi brings 38+ years of proficiency with virtually all analytical instrumentation and the techniques of Environmental, Petrochemical and Pharmaceutical testing and research. In his distinguished career, here are few highlights of his achievements.
1. 1992-1993 – He received a recognition from DuPont Company as non-DuPont employee for completing Recycled Vinyl Acetate project from conception to completion in record 10 months. This saved DuPont $12 million per year.
2. 1994-1998 – At Varian Inc., He received several awards as exemplary employee for outstanding customer service.
3. 2001 – At NASA being a principal investigator for Mars Exploration project, received several awards for Recycling of Water in Space project and several safety awards.
4. Since 2002 – He has shepherded several ASTM and USEPA methods, for example USEPA method 332.0 for “Perchlorate Analysis in water by ICMS”, USEPA Method 218.7 for “Analysis of Hexavalent Chromium in Drinking Water”
5. Currently he is globally involved with development of “Total Fluorine” analysis using Combustion Ion Chromatography (C-IC)
6. Since 2003, Dr. Gandhi is a non-paid adjunct faculty at University of Houston- Clearlake where he enjoys guiding graduate and post graduate students for their independent study program.
7. Loves listening to music of Kenny G, Mozart and Bach.
“I now have a better understanding of how HPLC works and why column choice is so important.”
“It is a fantastic course for learning the theory of LC and method development”
“The instructor, Merlin Bicking, is very helpful. It was great to see how wiling he is to answer questions and all the variety of methods he worked on.”
“I am just beginning my position from out of school. I found the course very insightful in terms of preparation for my future career”
“It is very useful for me because having hands on experience, which helped me to understand more of HPLC.”
“Great class. Would easily take again and recommend Dr. Merlin anytime. Would love to take his other courses. If he had a book would quickly buy for reference.”
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Last Updated: March 14, 2024 by CCDG
The Chicago Chromatography Discussion Group invites you to an in-person Dinner Meeting
Speaker: Dr. Jay Gandhi, Ph.D., Vertical Market Manager, Metrohm USA, Inc.
Title: Combustion Ion Chromatography
Location: Westwood Tavern Schaumburg, IL
Date: Thursday, April 18th, 2024
Time: 6pm – 9pm
REGISTER HERE
Join us for a dinner and networking event Thursday April 18, 2024, at the Westwood Tavern in Schaumburg, IL. The topics discussed will cover sample prep techniques for non-targeted analysis of PFAS using combustion ion chromatography. Due to their environmental persistence and potential implications on human health, the analysis of per-and polyfluoroalkyl substances, or PFAS, in the environment remains critical. Targeted analysis using LC-MS/MS has long been the analytical method of choice, due to its high sensitivity and specificity. With more than 3000 potential PFAS-type compounds, targeted analysis does not always allow for the assessment of the total impact of these compounds. Because of this, there has been increasing interest by regulatory committees in non-targeted analysis techniques, such as quantifying total organic fluorine (TOF), as a PFAS impact assessment. Combustion Ion Chromatography, or CIC, allows for the sensitive quantitation of TOF, ranging from single ppb to percent levels. In this technique, samples are combusted in a high temperature oven, where organofluorine bonds are broken to produce HF, which is subsequently absorbed into solution and analyzed by IC for fluorine. Prior to analysis by IC, inorganic, or free fluoride must be separated from the sample to prevent interference. A variety of techniques exist to accomplish removal of inorganic fluoride, such as the AOF (adsorbable organic fluorine) method, which captures organofluorine compounds on an activated charcoal bed and allows for removal of free fluoride through a rinsing step. The charcoal can then be analyzed by CIC. Other methods have also been investigated to further improve recovery of TOF, allowing for the non-targeted identification of PFAS compounds ranging from C1-C16+. A comparison of these methods will be presented.
Dr. Gandhi brings 38+ years of proficiency with virtually all analytical instrumentation and the techniques of Environmental, Petrochemical and Pharmaceutical testing and research. In his distinguished career, here are few highlights of his achievements.
1. 1992-1993 – He received a recognition from DuPont Company as non-DuPont employee for completing Recycled Vinyl Acetate project from conception to completion in record 10 months. This saved DuPont $12 million per year.
2. 1994-1998 – At Varian Inc., He received several awards as exemplary employee for outstanding customer service.
3. 2001 – At NASA being a principal investigator for Mars Exploration project, received several awards for Recycling of Water in Space project and several safety awards.
4. Since 2002 – He has shepherded several ASTM and USEPA methods, for example USEPA method 332.0 for “Perchlorate Analysis in water by ICMS”, USEPA Method 218.7 for “Analysis of Hexavalent Chromium in Drinking Water”
5. Currently he is globally involved with development of “Total Fluorine” analysis using Combustion Ion Chromatography (C-IC)
6. Since 2003, Dr. Gandhi is a non-paid adjunct faculty at University of Houston- Clearlake where he enjoys guiding graduate and post graduate students for their independent study program.
7. Loves listening to music of Kenny G, Mozart and Bach.
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LC School Reviews
“I now have a better understanding of how HPLC works and why column choice is so important.”
“It is a fantastic course for learning the theory of LC and method development”
“The instructor, Merlin Bicking, is very helpful. It was great to see how wiling he is to answer questions and all the variety of methods he worked on.”
“I am just beginning my position from out of school. I found the course very insightful in terms of preparation for my future career”
“It is very useful for me because having hands on experience, which helped me to understand more of HPLC.”
“Great class. Would easily take again and recommend Dr. Merlin anytime. Would love to take his other courses. If he had a book would quickly buy for reference.”