CCDG HPLC School 2025

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This course offers a well-designed combination of lecture and hands-on laboratory training. Students gain sufficient theoretical and practical background to perform independent work in liquid chromatography.

The three day course encompasses all major areas of liquid chromatography and related sample preparation techniques likely to be encountered by workers practicing in the field.

Experts active in the field of liquid chromatography lead the course and laboratory sessions.

A full day of intensive laboratory experiments gives the students, working as small teams, invaluable hands-on experience.

The latest high performance UHPLC/HPLC equipment, supplied by leading manufacturers, comprise the chromatographic instrumentation for students to use during the lab sessions. Technical experts from the various companies will guide students through the operation of the system.

Registration Deadline: September 30, 2025

Includes text, supplies, and lunches

Early Registration Discount (August 1 – August 31): $1100

Registration Fee after August 31: $1195

Student Price: $500

Location: Roosevelt University, 1400 N Roosevelt Blvd Schaumburg, IL 60173

Course is October 7- 9, 2025

8 am – 5pm each day

Printed course material is provided, at no extra cost to the student, by the Chicago Chromatography Discussion Group.

Course Instructor:Merlin K. L. Bicking, Ph.D.Woodbury, MN 55125Phone: (651) 731-3670 Fax: (651) 730-0965

Education:

  • Bachelor of Science – Chemistry
  • University of Wisconsin – River Falls, WI
  • Doctor of Philosophy – Organic-Analytical Chemistry
  • Iowa State University – Ames, IA

Dr. Merlin Bicking is the founder of ACCTA, Inc., an analytical chemistry training and consulting firm. With more than 30 years of post-graduate experience in academia, contract research, contract laboratory, and independent consulting, he provides basic through advanced level training on laboratory skills and use of analytical equipment. His expertise includes analytical separations, method development, and problem-solving, using a wide range of techniques including HPLC, GC, GC/MS, SFE, SFC, FTIR, NMR, and absorbance spectrophotometry. Dr. Bicking received a BS in Chemistry from the University of Wisconsin – River Falls and a Ph.D. in Organic-Analytical Chemistry from Iowa State University.

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CCDG Dinner Lecture: Perkin Elmer’s QSight500 LC-MS/MS with StayClean

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Join us for a dinner and networking event Wednesday September 10, 2025 at the Westwood Tavern in Schaumburg, IL. The lecture, presented by Autumn Payne, will cover learnings and insights of the newly released QSight500 UHPLC-triple quadrupole system, focusing on StayCleanTM technology that allows for increased robustness, better ion transmission, less contamination buildup and less required maintenance. StayCleanTM Ion Source is designed to handle increased matrix components while overcoming contamination buildup and avoiding subsequent interferences. The instrument performance will be highlighted by a variety of studies testing for robustness, and applications that Perkin Elmer has successfully implemented, including pesticide/herbicide/fungicide analysis and PFAS analysis in a variety of dirty matrices.

Bio:

Autumn Payne is a Field Application Scientist currently working at Perkin Elmer, specializing in LC and LC-MS/MS applications. She has been with the company for three years and is based out of Kalamazoo Michigan. Her previous experiences were as a lab manager and analyst in environmental testing laboratories. She operated a variety of instruments (ICP-OES, ICP-MS, GFAA, HPLC-UV, UHPLC-MS/MS, GC-FTIR, GC-MS) for the analysis of plants, drinking water and wastewater samples. She has a passion for delivering clean and safe products that are quality tested for potential contaminants of concern. She also values providing support for laboratories through the learning process with new instruments. In her free time, she enjoys adventuring outdoors and spending quality time with loved ones and her two handsome cats.

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Save the Date! 2025 CCDG: AN INTRODUCTORY COURSE IN LIQUID CHROMATOGRAPHY

Registration Details Coming Soon !

October 7 – 9, 2025

8:30 AM  4:00 PM

 Roosevelt University, Schaumburg Campus

1400 N Roosevelt Boulevard Schaumburg, IL 60173

Instructor: Merlin K. L. Bicking, PhD

Description

This course provides comprehensive theoretical and practical instruction to enable independent work in liquid chromatography. 2 days in the classroom are followed by a day in the laboratory where students, guided by representatives by all leading LC vendors, put into practice what they’ve learned.

Early Registration Discount

$ 1100 August 1 – August 31

$1195 after August 31

Students $500.00

Registration Details Coming Soon !

For questions, contact rich_demuro@waters.com

CCDG Dinner Lecture: Solid-Phase Extraction: All C18s Are Not the Same

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Join us for a dinner and networking event Wednesday April 16, 2025 at the Westwood Tavern in Schaumburg, IL. The lecture, presented by Don Shelly, will cover learnings and insights on how all C18s are not created equal in solid-phase extraction. This presentation will present blind performance data from multiple sorbent manufacturers’ C18s and how their C18s compare under duplicate extraction conditions. Other helpful information will be included.

CCDG Dinner Lecture: Streamlining the Complexities of Method Development

Join us for a dinner and networking event Thursday March 13, 2025 at the Westwood Tavern in Schaumburg, IL. The lecture, presented by Nivesh Mittal, will cover learnings and insights on a cutting-edge platform designed to streamline the complexities of method development.

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Driven by the recent revisions in ICH Q2(R2) and the introduction of Q14, the adoption of Analytical Quality by Design (AQbD) principles has become increasingly critical for analytical method development . This risk-based approach emphasizes a thorough understanding of analytical methods through systematic experimentation, including Design of Experiments (DoE) and the establishment of a design space to elucidate the impact of method parameters on analytical results. This paradigm shift facilitates the development of robust and reliable methods with minimized risk, independent of an analyst’s experience.

LabSolutions MD is a cutting-edge AQbD-driven platform designed to streamline the complexities of method development. By simplifying the critical phases of method development—screening, optimization, and robustness testing—LabSolutions MD empowers users to navigate the challenges of traditional method development with ease. This presentation will delve into the limitations of manual method development and showcase how LabSolutions MD provides innovative tools to overcome these obstacles. Furthermore, real-world case studies from the pharmaceutical and biopharmaceutical sectors will be presented, highlighting the successful implementation of LabSolutions MD in diverse analytical workflows.

Upcoming! CCDG Dinner Lecture: Food packaging and LCMS risk analysis

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Join us for a dinner and networking event Wednesday December 4, 2024 at the Westwood Tavern in Schaumburg, IL. The lecture, presented by Natasha Hausler Banke PhD, will cover learnings and insights on In-Situ analysis of the presence of a photoinitiator after curing.

Over the past few years, regulatory reclassifications have continued to change how ink  manufacturers world-wide formulate UV cured inks. Adding a chemical to the European Chemicals  Agency (ECHA) Substances of Very High Concern (SVHC) list triggers changes in regulatory  reporting. Manufacturers and importers of articles which contain the SVHC become legally required to  notify customers/consumers if the concentration is greater than 0.1% w/w. In addition, ECHA must be  notified if the total amount of SVHC imported into an EU country is greater than 1 metric ton/ year. While inclusion on the list is not a ban on use, it has this effect for ink manufacturers. For example,  member companies of the European Printing Ink Association (EuPIA) agree to abide by the Exclusion  Policy, which requires formulating inks away from the use of an SVHC. Additionally, brand owners  may have similar requirements for packaging and printing inks. Under general exclusions for ink  formulations, the Nestlé guidance states an SVHC “must not be used where suitable alternatives exist.”  In contrast to some European regulations, the USFDA does not explicitly regulate the contents of  printing ink. However, the USFDA does regulate the food additives. Subsequently, it is the  responsibility of the manufacturer of a food contact substance (FCS) to ensure the FCM is consistent  with applicable authorizations and does not adulterate food. 

Differing regulations between Europe and the US frequently lead to fit-for-use questions of ink  formulations. We are commonly asked what substances are acceptable for use and what residual ink  components are present in the matrix of the cured print. In response to previous customer questions and  regulatory changes, INX has undertaken several studies to evaluate exposure of an SVHC during the  manufacturing process. As an extension of previously completed work, the current study evaluates the  presence of residual PI369 in a cured print and determine if that print contains levels of the residual  SVHC above labeling requirements in the EU (0.1%). 

Natasha Hausler Banke, PhD – Director, Analytical R&D INX International Ink Company

The Chicago Chromatography Discussion Group invites you to an in-person Dinner Meeting

Title: Tripping into Chromatography

Speakers:

Leonard Lerer

Founder and CSO – Back of the Yards Algae Sciences (BYAS)-ParowBio

Sean Johnston

Director of Analytical Laboratory – BYAS-ParowBio

Alex Buko

Vice President Human Metabolome Technologies America

Geoffrey Todosiev

President, MetaPür Inc

Location: Westwood Tavern Schaumburg, IL

Date: Wednesday May 8, 2024

Time: 6pm – 9pm

REGISTER HERE

Join us for a dinner and networking event Wednesday May 8,2024 at the Westwood Tavern in Schaumburg, IL. The topics discussed will cover our learnings and humble insights from an almost 4-year journey into chromatography including HPLC, separation and preparative chromatography, UHPLC-MS, centrifugal partition chromatography (CPC), LC-MS/MS, CEMS metabolomics and MS imaging (DESI-TOF).

Leonard Lerer will present published and in-progress research highlighting the pivotal role of chromatography.

Sean Johnston will discuss the operational challenges and successes of operating a small biotechnology analytical chemistry laboratory and review their work in method development and quality assurance.

Alex Buko will present the resolution and sensitivity advantages of CEMS and the operation of DESI-TOF.

Geoffrey Todosiev will present the scale-up potential from milligram scale to kilo scale chromatographic purification.

The Chicago Chromatography Discussion Group invites you to an in-person Dinner Meeting

Speaker: Dr. Jay Gandhi, Ph.D., Vertical Market Manager, Metrohm USA, Inc.

Title: Combustion Ion Chromatography

Location: Westwood Tavern Schaumburg, IL

Date: Thursday, April 18th, 2024

Time: 6pm – 9pm

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Join us for a dinner and networking event Thursday April 18, 2024, at the Westwood Tavern in Schaumburg, IL. The topics discussed will cover sample prep techniques for non-targeted analysis of PFAS using combustion ion chromatography. Due to their environmental persistence and potential implications on human health, the analysis of per-and polyfluoroalkyl substances, or PFAS, in the environment remains critical. Targeted analysis using LC-MS/MS has long been the analytical method of choice, due to its high sensitivity and specificity. With more than 3000 potential PFAS-type compounds, targeted analysis does not always allow for the assessment of the total impact of these compounds. Because of this, there has been increasing interest by regulatory committees in non-targeted analysis techniques, such as quantifying total organic fluorine (TOF), as a PFAS impact assessment. Combustion Ion Chromatography, or CIC, allows for the sensitive quantitation of TOF, ranging from single ppb to percent levels. In this technique, samples are combusted in a high temperature oven, where organofluorine bonds are broken to produce HF, which is subsequently absorbed into solution and analyzed by IC for fluorine. Prior to analysis by IC, inorganic, or free fluoride must be separated from the sample to prevent interference. A variety of techniques exist to accomplish removal of inorganic fluoride, such as the AOF (adsorbable organic fluorine) method, which captures organofluorine compounds on an activated charcoal bed and allows for removal of free fluoride through a rinsing step. The charcoal can then be analyzed by CIC. Other methods have also been investigated to further improve recovery of TOF, allowing for the non-targeted identification of PFAS compounds ranging from C1-C16+. A comparison of these methods will be presented.

Dr. Gandhi brings 38+ years of proficiency with virtually all analytical instrumentation and the techniques of Environmental, Petrochemical and Pharmaceutical testing and research. In his distinguished career, here are few highlights of his achievements.

1. 1992-1993 – He received a recognition from DuPont Company as non-DuPont employee for completing Recycled Vinyl Acetate project from conception to completion in record 10 months. This saved DuPont $12 million per year.

2. 1994-1998 – At Varian Inc., He received several awards as exemplary employee for outstanding customer service.

3. 2001 – At NASA being a principal investigator for Mars Exploration project, received several awards for Recycling of Water in Space project and several safety awards.

4. Since 2002 – He has shepherded several ASTM and USEPA methods, for example USEPA method 332.0 for “Perchlorate Analysis in water by ICMS”, USEPA Method 218.7 for “Analysis of Hexavalent Chromium in Drinking Water”

5. Currently he is globally involved with development of “Total Fluorine” analysis using Combustion Ion Chromatography (C-IC)

6. Since 2003, Dr. Gandhi is a non-paid adjunct faculty at University of Houston- Clearlake where he enjoys guiding graduate and post graduate students for their independent study program.

7. Loves listening to music of Kenny G, Mozart and Bach.

Dinner Lecture: Emerging Hybrid Separation Techniques for the Analysis of New Psychoactive Substances

The Chicago Chromatography Discussion Group invites you to an in-person Dinner Meeting
Speaker: Professor Ira Lurie Ph.D. Adjunct Professor, Research Professor Department of Forensic Sciences George Washington University


Location: Westwood Tavern Schaumburg, IL
Date: Tuesday December 5th, 2023 Time: 6pm – 9pm

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Join us for a dinner and networking event on December 5th, 2023, at the Westwood Tavern in Schaumburg, IL. For screening and confirmation purposes hybrid techniques employing a separation and detection step are routinely employed. In this vein the specificity of analysis depends on the performance of both techniques working in tandem. Ultra-high performance supercritical fluid chromatography (UHPSFC) and ultra-high performance liquid chromatography (UHPLC) provide for uncorrelated separations compared to gas chromatography (GC) and thus a complementary technique to gas phase separations which is very useful for the analysis of novel psychoactive substances (NPS), particularly for positional isomers and diastereomers. Ultra-high performance supercritical fluid chromatography has been found to outperform UHPLC and GC for the separation of these analytes. The use of flip flop chromatography allows for uncorrelated UHPLC multi-modal separations on the same column without changing the contents of the solvent reservoir. Electron ionization (EI) mass spectrometry for several classes of emerging drugs is lacking in the production of molecular ions. Techniques such as cold EI MS coupled to GC, and electrospray ionization (ESI) MS coupled to UHPLC and UHPSFC can overcome this limitation. Electron ionization mass spectrometry can be problematic for distinguishing positional isomers and diastereomers, for which vacuum ultraviolet (VUV) detection coupled with GC, and ultraviolet detection coupled to UHPLC, and UHPSFC can offer solutions. The use of a portable LC employing two capillary columns in series with dual wavelength UV detection will be discussed.
Professor Ira Lurie received his BA in chemistry from Queens College in Queens, New York, and his MS in chemistry from Rutgers University, New Brunswick New Jersey. Dr. Lurie received his Ph.D. in chemistry from the University of Amsterdam, The Netherlands, under the direction of Professor Peter Schoenmakers, where his thesis described the use of ultra-high performance liquid chromatography (UHPLC) for the analysis of seized drugs. He is retired from the United States Drug Enforcement Administration where he served for almost 40 years as both a forensic chemist and a research chemist developing methods liquid phase techniques for drug profiling. During his tenure with the DEA, he served as the agency’s expert in liquid phase separations. Along with Dr. Bob Weinberger Dr. Lurie pioneered the use of capillary electrophoresis for seized drug analysis. Professor Lurie has co-edited a book, authored, or co-authored 7 book chapters and over 80 peer reviewed articles. In this vein, he was recently listed as one of the top 25 most cited authors in forensic science in the United States. Dr. Lurie is a fellow of the American Academy of Forensic Sciences (AAFS) from whom he was the winner of the 2015 Paul L. Kirk Award, the highest form of recognition from the Criminalistics Section of the AAFS. His research interests include the investigation of novel separation and detection techniques for drug analysis i.e., ultra-high performance supercritical fluid chromatography (UHPSFC), multi-modal separations, the use of a portable liquid chromatograph, and gas chromatography (GC) coupled to cold electron ionization mass spectrometry and/or vacuum ultraviolet detection.

Election Results

On May 22, 2023, CCDG held its open board meeting and the following are the results of the election.

President
Stephanie Collins

President Elect
Opens in May 2025

Secretary
Olivia Cavazos

Secretary Elect
Opens in May 2025

Treasurer
Robin Sutka, Ph.D.

Sponsorship Chair
Joe Jones, Ph.D.

Past President
James DeFrancesco, Ph.D.

Awards Chair
Sara Plowman

Communications Chairs
Mary Jones, Vanessa Szul, & Patrick Barth

GC School Chairs
Cole Gardner, Vanessa Szul, & Sara Plowman

LC School Chairs
Rich DeMuro, Adam Dill, & Lori Sandford

Membership Chair
Natasha Banke, Ph.D.

Programs Chair
Madeline Angles

Congratulations to all!